PURPOSE: To obtain the subject new compound excellent in safety useful as a medicine for preventing, treating and improving diseases effective when using a dopamine D3 receptor-antagonizing action therefor, especially as a treating and improving medicine of schizophrenia, high in usability in clinical field.
CONSTITUTION: A compound of formula I [R1, R2 are each H, OH, a halogen, a lower alkoxy, amino, a lower alkyl; R3 is H, a lower alkyl; R4 is a group of formula II (R5, R6 are each H, a halogen, a lower alkyl; (r) is 0, 1), a group of formula III, a group of formula IV, etc.; (m) is 2-4; (n) is 1-3], its salt. For example, N-[(4-{N'-methyl-N'-[2-(3,5-dimethoxy)phenetyl]amino}butyl)]-(4fluoro) cinnamide. The exampled compound is obtained by reacting p-fluorocinnamic acid with N-methyl-N-(3,5-dimethoxyphenetyl)-1,4-diaminobutane.
| JPH09278657 | USE OF ANTACID AND ANTACID-FORMULATED PREPARATION |
| WO/2002/018320 | INHIBITORS OF $g(a)4 MEDIATED CELL ADHESION |
| WO/2004/012506 | ANTIMICROBIAL COMPOUNDS |
OZAKI FUMIHIRO
FUJISAKI HIDEAKI
AOKI MIKA
KAGAYA YOSHIKI
KUROKI ATSUSHI
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