ASYMMETRIC HETEROCYCLIC ESTER DERIVATIVE OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID AND PREPARATION

Japanese Patent JPS61194084

A

The present invention relates to new asymmetric heterocyclic ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids of the formula: (I) wherein R1 is a C1-C4-alkyl group; X and Y, which are identical or different, each represent O or S, at least one of the symbols X and Y being different from S; n is an integer equal to 1 or 2; and R2 and R3, which are identical or different, each represent H, CH3, CF3, C6H5 or halogenophenyl, it being possible for R2 and R3, taken together, to form a 5-membered to 7-membered spirocycloaliphatic group with the C atom of the heterocyclic group to which they are bonded; and their optical iomers and diastereoisomers. These new derivatives are useful as pharmaceuticals, in particular as vasodilators.

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JIYATSUKU ROBAN
JIJIE PURIYUNOO
ARAN BONANFUAN

JP3813186A

August 28, 1986

February 20, 1986

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SORI SOC RECH IND

A61K31/44; A61K31/443; A61P9/08; A61P9/10; A61P9/12; C07D317/00; C07D317/24; C07D317/72; C07D327/00; C07D327/04; C07D405/12; C07D409/12; C07D411/12; (IPC1-7): A61K31/44; C07D211/00; C07D317/00; C07D317/24; C07D317/72; C07D327/00; C07D327/04; C07D405/12; C07D411/12

Bunji Kamada

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