Title:
ベンゼンスルホニル-クロマン、チオクロマン、テトラヒドロナフタレン、および関連するガンマセクレターゼインヒビター
Document Type and Number:
Japanese Patent JP5204227
Kind Code:
B2
Abstract:
Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.
Inventors:
Sashikumar, Sabarakuramugarakei.
Burnett, Duane A.
Asbelom, Theodoros
Wu, Wen-Liang
Lee, Hong Mei
Sue, Luo
Jussien, Hubert Bee.
Burnett, Duane A.
Asbelom, Theodoros
Wu, Wen-Liang
Lee, Hong Mei
Sue, Luo
Jussien, Hubert Bee.
Application Number:
JP2010517007A
Publication Date:
June 05, 2013
Filing Date:
July 15, 2008
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D491/052; A61K31/365; A61K31/407; A61K31/4162; A61K31/436; A61K31/519; A61K31/542; A61K31/549; A61K45/00; A61P25/28; A61P43/00; C07D491/147; C07D493/04; C07D513/04; C07D513/14
Foreign References:
| WO2003014075A1 | ||||
| WO2004031137A1 | ||||
| WO2004101539A1 | ||||
| WO2007143523A1 | ||||
| WO2009008980A1 | ||||
| WO2007084595A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita