Title:
5-HT4受容体作動活性を有するベンズイミダゾロン化合物
Document Type and Number:
Japanese Patent JP3983269
Kind Code:
B1
Abstract:
This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
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Inventors:
Satoshi Iguchi
Yasuhiro Katsu
Daiki Sone
Riki Uchida
Takashi Kojima
Yasuhiro Katsu
Daiki Sone
Riki Uchida
Takashi Kojima
Application Number:
JP2006525197A
Publication Date:
September 26, 2007
Filing Date:
August 20, 2004
Export Citation:
Assignee:
Pfizer Japan Inc
International Classes:
C07D401/12; A61K31/454; A61K31/46; A61K31/5377; A61P1/00; A61P1/04; A61P1/10; A61P1/12; A61P1/14; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P11/00; A61P25/00; A61P25/06; A61P25/28; C07D405/06; C07D405/14; C07D413/14; C07D451/02; C07D471/04
Domestic Patent References:
| JP7504428A | ||||
| JP11501640A | ||||
| JP4235161A |
Foreign References:
| US3541155 | ||||
| WO2003037916A1 |
Other References:
伊国特許第1298271号明細書
J.Med.Chem.,1999年,Vol.42,No.15,pp.2870-2880
J.Med.Chem.,1999年,Vol.42,No.15,pp.2870-2880
Attorney, Agent or Firm:
Yoshinobu Murofushi