Title:
肺および心血管障害を治療するためのビアリールPDE4抑制剤
Document Type and Number:
Japanese Patent JP2011504505
Kind Code:
A
Abstract:
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I:
Inventors:
Sing, Jasbah
Gurney,mark
Virgin, alex
Kiselev, Alexander
Lao, Munagara
Hagen, timothy
Gurney,mark
Virgin, alex
Kiselev, Alexander
Lao, Munagara
Hagen, timothy
Application Number:
JP2010535073A
Publication Date:
February 10, 2011
Filing Date:
November 20, 2008
Export Citation:
Assignee:
Decode Genetics EHF
International Classes:
C07C307/10; A61K31/17; A61K31/18; A61K31/192; A61K31/235; A61K31/40; A61K31/415; A61K31/428; A61K31/433; A61K31/437; A61K31/4412; A61K31/4425; A61K31/4427; A61K31/4439; A61K31/4545; A61K31/505; A61K31/506; A61K31/52; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/10; A61P19/08; A61P35/00; A61P43/00; C07C69/76; C07C275/28; C07D207/16; C07D213/65; C07D213/79; C07D213/81; C07D231/12; C07D239/42; C07D275/06; C07D285/12; C07D285/135; C07D401/04; C07D401/06; C07D403/06; C07D471/04; C07D473/18; C07D473/32
Domestic Patent References:
| JPS62249939A | 1987-10-30 | |||
| JPH11515008A | 1999-12-21 | |||
| JPH11508264A | 1999-07-21 | |||
| JPH10114724A | 1998-05-06 | |||
| JP2007512359A | 2007-05-17 |
Foreign References:
| EP0894794A1 | 1999-02-03 | |||
| WO2007039075A2 | 2007-04-12 | |||
| WO2004093799A2 | 2004-11-04 | |||
| WO2008001959A1 | 2008-01-03 | |||
| WO2006056854A1 | 2006-06-01 | |||
| US5594141A | 1997-01-14 | |||
| WO1999031062A1 | 1999-06-24 |
Other References:
BABU, SRINIVASARAO ARULANANDA; YASUDA, MAKOTO; BABA, AKIO: "In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe2SiH with Carboxylic Acids: Direc", ORGANIC LETTERS, vol. 9(3), JPN6013049918, 2007, pages 405 - 408, ISSN: 0002649897
CHAPMAN, GLEN M. ET AL.: "Synthesis of novel poly(dithienylpyridines)", JOURNAL OF MATERIALS CHEMISTRY, vol. 12(8), JPN6013049919, 2002, pages 2292 - 2298, ISSN: 0002649898
SMIRNOV, L. D.; KUZ'MIN, V. I.; ZBARSKII, A. E.; LEZINA, V. P.; DYUMAEV, K. M.: "Synthesis and study of some electrophilic reactions of 2-phenyl-3-hydroxypyridine N-oxides", IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA, vol. (4), JPN6013049920, 1973, pages 861 - 4, ISSN: 0002649899
CHAPMAN, GLEN M. ET AL.: "Synthesis of novel poly(dithienylpyridines)", JOURNAL OF MATERIALS CHEMISTRY, vol. 12(8), JPN6013049919, 2002, pages 2292 - 2298, ISSN: 0002649898
SMIRNOV, L. D.; KUZ'MIN, V. I.; ZBARSKII, A. E.; LEZINA, V. P.; DYUMAEV, K. M.: "Synthesis and study of some electrophilic reactions of 2-phenyl-3-hydroxypyridine N-oxides", IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA, vol. (4), JPN6013049920, 1973, pages 861 - 4, ISSN: 0002649899
Attorney, Agent or Firm:
Kenichi Morita
Kenjiro Yamaguchi
Kenjiro Yamaguchi