Title:
HIVインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体
Document Type and Number:
Japanese Patent JP5317257
Kind Code:
B2
Abstract:
[Object] Is to provide a novel compound having an anti-viral activity, particularly a HIV integrase inhibitory activity, and an agent, particularly an anti-HIV agent. [Solving means] A compound represented by the formula:
(wherein
Z 1 is NR 4 (R 4 is hydrogen, optionally substituted lower alkyl etc.), O or CH 2 ;
Z 2 is optionally substituted lower alkylene or optionally substituted lower alkenylene, each may be intervened by a heteroatom group selected from group consisting O, S, SO, SO 2 , NR 5 (R 5 is selected independently from the same substituent group of R 4 ) -N= and =N-;
R 1 is hydrogen or lower alkyl;
X is a single bond, a heteroatom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene each may be intervened by the heteroatom group;
R 2 is optionally substituted aryl;
R 3 is hydrogen, halogen, hydroxy, optionally substituted alkyl group etc.)
Inventors:
Hiroshi Yoshida
Takashi Kawasuji
Yoshiyuki Amada
Takashi Kawasuji
Yoshiyuki Amada
Application Number:
JP2007503763A
Publication Date:
October 16, 2013
Filing Date:
February 20, 2006
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D471/04; A61K31/4985; A61P31/18; A61P43/00
Domestic Patent References:
| JP2004511483A | 2004-04-15 | |||
| JP2004510819A | 2004-04-08 | |||
| JP2004511483A | 2004-04-15 | |||
| JP2004510819A | 2004-04-08 |
Foreign References:
| WO2004058756A1 | 2004-07-15 | |||
| WO2004024078A2 | 2004-03-25 | |||
| WO2005016927A1 | 2005-02-24 | |||
| WO2005016927A1 | 2005-02-24 | |||
| WO2004058756A1 | 2004-07-15 | |||
| WO2004024078A2 | 2004-03-25 |
Attorney, Agent or Firm:
Kenichi Sugita
Hiromitsu Takayama
Hiromitsu Takayama