Title:
ビス-アリールスルホンアミド
Document Type and Number:
Japanese Patent JP2006510724
Kind Code:
A
Abstract:
Compounds of formula (I)
(in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
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Inventors:
Angashe, Solomon
Way,chen
Wright, Jay Jay
Andrew Pennell
Premac, bullet
Shall, Thomas Jay
Way,chen
Wright, Jay Jay
Andrew Pennell
Premac, bullet
Shall, Thomas Jay
Application Number:
JP2004569975A
Publication Date:
March 30, 2006
Filing Date:
November 18, 2003
Export Citation:
Assignee:
Chemocentrix, Incorporated
International Classes:
A61K31/18; A61K31/275; A61K31/343; A61K31/381; A61K31/421; A61K31/63; A61K31/635; A61K45/00; A61P1/04; A61P11/06; A61P17/06; A61P17/16; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D213/26; C07D213/50; C07D213/70; C07D213/74; C07D213/84; C07D213/89; C07D241/12; C07D413/12; C07D231/12; C07D263/32; C07D307/79; C07D333/18
Domestic Patent References:
| JP2005526857A | 2005-09-08 |
Foreign References:
| DE3544409A1 | 1986-10-16 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho