CETP阻害薬

Japanese Patent JP4922924

B2

Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.

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Ali, Amjiyad
Bourne, Jioan
Ton, thiaolin
Lou, Cheech Yang
Sinclair, Peter Theei
Taylor, Gale E
Thompson, Christopher Eff
Clichy, Natsuia

JP2007508428A

April 25, 2012

April 08, 2005

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Merck Sharp End Dome Corporation

C07C233/18; A61K31/165; A61K31/17; A61K31/18; A61K31/27; A61K31/277; A61K31/341; A61K31/343; A61K31/381; A61K31/404; A61K31/42; A61K31/4245; A61K31/4418; A61K31/4425; A61K31/47; A61P3/06; A61P9/10; A61P43/00; C07C205/00; C07C229/00; C07C271/14; C07C271/16; C07C271/18; C07C271/20; C07C271/22; C07C275/24; C07C279/08; C07C311/04; C07C311/05; C07C311/08; C07C317/32; C07C323/43; C07C333/04; C07D209/08; C07D209/10; C07D213/40; C07D213/64; C07D213/65; C07D213/68; C07D213/89; C07D215/12; C07D215/26; C07D217/02; C07D217/14; C07D261/08; C07D271/06; C07D307/52; C07D307/79; C07D307/81; C07D333/20; C07D333/22; C07D333/28

JP2004506008A	2004-02-26
JP2003515592A	2003-05-07
JP2002525351A	2002-08-13
JP2002525350A	2002-08-13
JP2002525348A	2002-08-13
JP2003221376A	2003-08-05

WO2004092136A1

2004-10-28

Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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