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Title:
CROSSLINKED NUCLEIC ACID GuNA, AND PRODUCTION METHOD AND INTERMEDIATE COMPOUND THEREOF
Document Type and Number:
Japanese Patent JP2022033869
Kind Code:
A
Abstract:
To provide a method for producing guanidine crosslinked artificial nucleic acid (GuNA), and an intermediate compound for production thereof.SOLUTION: A method for producing a compound represented by general formula I or a salt thereof comprises introducing a 2'-position amino group by expanding an azide methyl group from a 4'-position carbon atom and thereby bridging with 2'-position carbon atom.SELECTED DRAWING: None

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Inventors:
OBIKA SATOSHI
KAWANISHI EIJI
SAWAMOTO HIROAKI
YAMAGOSHI SHUHEI
ARAI YUKI
KUMAGAI SHINJI
Application Number:
JP2021195554A
Publication Date:
March 02, 2022
Filing Date:
December 01, 2021
Export Citation:
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Assignee:
MITSUBISHI TANABE PHARMA CORP
UNIV OSAKA
International Classes:
C07H9/06; C07H19/06; C07H19/16; C07H21/00; C12N15/10; C12N15/11; C12N15/113; C12N15/115
Domestic Patent References:
JP6994197B22022-01-14
JP2002521310A2002-07-16
JPH09328497A1997-12-22
Foreign References:
WO2014046212A12014-03-27
WO2007145593A12007-12-21
WO2011156202A12011-12-15
WO2014124952A12014-08-21
WO2016100569A12016-06-23
WO2016145142A12016-09-15
WO2003095467A12003-11-20
WO2011052436A12011-05-05
WO1998039352A11998-09-11
WO2005021570A12005-03-10
Other References:
SHRESTHA,A.R. ET AL, CHEM.COMMUN., vol. 50, JPN6016048654, 2014, pages 575 - 577, ISSN: 0004965998
SALINAS,J.C. ET AL, J.ORG.CHEM., vol. 79, JPN6016048659, 2014, pages 11651 - 11660, ISSN: 0004966002
BARMAN,J. ET AL, RSC ADV., vol. 5, JPN6016048655, 2015, pages 12257 - 12260, ISSN: 0004966003
MADSEN,A.S. ET AL, J.ORG.CHEM., vol. 77, JPN6016048656, 2012, pages 10718 - 10728, ISSN: 0004965999
HANESSIAN,S. ET AL, J.ORG.CHEM., vol. 78, JPN6016048657, 2013, pages 9064 - 9075, ISSN: 0004966000
KITANO,K. ET AL, TETRAHEDRON, vol. 53, no. 39, JPN6016048658, 1997, pages 13315 - 13322, ISSN: 0004966001
Attorney, Agent or Firm:
Yamato Kento
Sei Morimoto
Nobuhiko Akiyama



 
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