Title:
CARBAMATE CASPASE INHIBITOR AND USE THEREOF
Document Type and Number:
Japanese Patent JP2008266348
Kind Code:
A
Abstract:
To provide a caspase inhibitor which is an effective inhibitor of apoptosis and IL-1 secretion.
The caspase inhibitor is represented by formula (I) (wherein Z is oxygen or sulfur; R1 is hydrogen, -CHN2, -R, -CH2OR, -CH2SR or -CH2Y; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosters thereof; R3 is a group fitting to the S2 subsite of a caspase enzyme; R4 and R5 are taken together with the intervening nitrogen to form heterocyclic ring; and R is as described in the specification).
Inventors:
BEBBINGTON DAVID
CHARRIER JEAN-DAMIEN
KAY DAVID
KNEGTEL RONALD
GOLEC JULIAN
MORTIMORE MICHAEL
STUDLEY JOHN
CHARRIER JEAN-DAMIEN
KAY DAVID
KNEGTEL RONALD
GOLEC JULIAN
MORTIMORE MICHAEL
STUDLEY JOHN
Application Number:
JP2008153569A
Publication Date:
November 06, 2008
Filing Date:
June 11, 2008
Export Citation:
Assignee:
VERTEX PHARMACEUT INC
International Classes:
C07D209/04; A61K31/403; A61K31/404; A61K31/473; A61K31/496; A61K31/5415; A61K31/55; A61K31/575; A61K31/58; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P17/14; A61P19/02; A61P19/08; A61P21/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P25/30; A61P25/32; A61P29/00; A61P31/04; A61P31/06; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07D209/08; C07D209/82; C07D209/86; C07D221/12; C07D223/22; C07D223/26; C07D223/28; C07D279/22; C07D279/30; C07D279/36; C07D403/12; C07J9/00; C07J43/00
Domestic Patent References:
| JP4298200B2 | 2009-07-15 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita