PURPOSE: To provide the novel compd. useful as an antibacterial agent.
CONSTITUTION: This compd. is expressed by formula I (R is H, carboxylic acid protective group; R1 is H lower alkyl, etc.; R2, R3 are each H, lower alkoxy, etc.; Y is ester, piperadinyl, etc.; where this ester is bonded to substd. quinolonyl, etc., and further, the piperadinyl includes a piperadinyl nucleus having an N atom to be bonded to naphthylidony, etc.), its ester, its salt and its hydrate; for example, raceme-[5R,6S(R)]-3-[[[6,8-difluoro-1-(2-fluoroethyl)-1, 4-dihydro-4-oxo-7-(4-methyl-1-piperadinyl-3-quinolonyl]carbonyl]oxy]methyl-6-(1- hydroxyethyl)-7-oxo-1-azabicyclo-[3,2,0]hep-2-ten-carboxylic acid. The compd. is obtd. by bringing, for example, the compd. of formula II (R6 is an ester residue; X is H) into reaction with substd. isothiazoloquinolone.
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DENISU DORUTON KIISU
PAMERA RORIIN ROSUMAN
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