CATIONIC LIPID - KYOWA HAKKO KIRIN CO LTD

Title:

CATIONIC LIPID

Document Type and Number:

Japanese Patent JP2018030844

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a novel cationic lipid which allows nucleic acids to be easily introduced into cells, and a novel composition containing the cationic lipid.SOLUTION: The present invention provides a cationic lipid, such as (3R,4R)-3,4-bis((9Z,12Z)-octadec-9,12-dienyloxy) pyrrolidine and (3R,4R)-pyrrolidine-3,4-diyl di((9Z,12Z)-octadec-9,12-dienoate), derivatives of dihydroxypyrrolidine, or N-methyl-N, N-bis(2-((9Z,12Z)-octadec-9,12-dienyloxy) ethyl) amine and N, N-bis(2-((Z)-octadec-9-enyloxy) ethyl) amine, derivatives of bis(hydroxyethyl) amine.SELECTED DRAWING: None

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Inventors:

KUBOYAMA TAKESHI
ERA TOMOHIRO
NAOI TOMOYUKI
YAGI NOBUHIRO

Application Number:

JP2017168131A

Publication Date:

March 01, 2018

Filing Date:

September 01, 2017

Export Citation:

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Assignee:

KYOWA HAKKO KIRIN CO LTD

International Classes:

A61K31/713; C07C217/08; A61K47/54; A61K48/00; A61P29/00; A61P35/00; C07C219/08; C07C237/06; C07C237/08; C07C271/16; C07D207/08; C07D207/12; C07D401/04; C07D491/056; C12N15/00; C12N15/113

Attorney, Agent or Firm:

Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Taku Yamada

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