NEW MATERIAL: A compound of formula I [Y is O, S, -SO-, -SO2- or -CH2-; R1 is (substd.) phenyl, cyclohexenyl, cyclohexadienyl, etc.; R2 is C1-8 alkyl; OC2R3 is carboxyl or carboxylic anion; R3 is carboxyl-protecting group; formula II is pyridinium attached to S via ring carbon atom; R4 and R5 are each H, (substd.) C1-6 alkyl, (substd.) C3-7 cyaloalkyl, etc.; X is inorganic or organic anion; n is 0 or 1; the asterisk * is asymmetric carbon atom].
EXAMPLE: [6R,7R]-3-[1-(3,4-dihydroxybenzoylamino)pyridinium-4- thiomethyl]-7-[[R]-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino]-2- phenylacetamido]-7-formamido-ceph-3-em-4-carboxylate.
USE: Therapeutic agents for gram-negative bacterial infection.
PROCESS: A compound of formula III (R11 is a leaving group) is treated with a thiopyridone compound of formula IV.
ENJIERA UENDEE GESUTO
SUTEFUAN KURISUTOFUAA FUINCHI
