Title:
セフェム化合物
Document Type and Number:
Japanese Patent JP2006528970
Kind Code:
A
Abstract:
The present invention is concerned with a novel cephem compound, with a process for the production of this compound, which process may contain or consist of fermentative steps, chemical steps, and/or biotransformation steps. A cephem compound according to the present invention characterised by formula (I) or a salt or ester thereof, wherein R is selected from the group consisting of (carboxymethylthio)propionyl (carboxyethylthio)propionyl Y-CH2-CO15 wherein Y is phenyl, phenoxy or tetrazolyl HOOC-X-CO wherein X is defined as (CH2)4 or wherein X is defined as (CH2)P-A-(CH2)q, wherein p and q each individually are 0, 1, 2, 3 or 4, and A is CH-CH, C--C, CHB, C-O, O, S, NH, the nitrogen optionally being substituted or the sulfur optionally being oxidized, and B is hydrogen, halogen, C1-3 alkoxy, hydroxyl, or optionally substituted methyl, with the proviso that p+q should be 2 or 3, when A is CH-CH or C--C, or p+q should be 3 or 4, when A is CHB, C-O, 0, S or NH or wherein X is (CH2)m-CH=A-(CH2)n or (CH2)m-C--C-(CH2)n, wherein m and n each individually are 0, 1, 2 or 3 and m+n=2 or 3, and A is CH or N, or wherein X is (CH2)p-CH-CH-C H-C-(CH2)q wherein p and q each individually are 0 or 1 and p+q=0 or 1 and wherein R' is selected from the group consisting of OH O-(alkyl 1-6C) wherein the alkyl can be straight or branched and O-C(alkyl 1-6C)-O-(alkyl 1-6C) wherein the alkyl groups can be straight or branched can inter alia be prepared by fermentative techniques according to the invention and in particular using a suitable microorganism possessing or being transformed with the genes needed for conversion of an appropriate acyl-6-aminopenicillanic acid into the desired compound.
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Inventors:
Van den berg, marco, alexander
Bovenberg, roelov, alui, lance
Ramsdonk, Lourina, Madeleine, Leon
Sutherland, John, David
Dev Room, Eric
Vollinga, Loeland, Christine, Roel
Bovenberg, roelov, alui, lance
Ramsdonk, Lourina, Madeleine, Leon
Sutherland, John, David
Dev Room, Eric
Vollinga, Loeland, Christine, Roel
Application Number:
JP2006532131A
Publication Date:
December 28, 2006
Filing Date:
May 24, 2004
Export Citation:
Assignee:
DSM Assets B. V.
International Classes:
C07D501/24; A61K31/545; A61P31/04; C07D501/00; C12N1/15; C12N15/09
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Masakazu Noda
Yoshinori Shimizu