Title:
マトリクスメタロプロテイナーゼ阻害物質としてのクロモン誘導体
Document Type and Number:
Japanese Patent JP2005539020
Kind Code:
A
Abstract:
This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y2, Y3, Y4, U5, U6, U8, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP-13 enzyme in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency, inflammatory bowel disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active component as described in the specification.
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Inventors:
Ortowine, Daniel Fred
Application Number:
JP2004527218A
Publication Date:
December 22, 2005
Filing Date:
August 04, 2003
Export Citation:
Assignee:
Warner-Lambert Company Limited Liability Company
International Classes:
A61K31/353; A61K31/536; A61P1/02; A61P1/04; A61P9/04; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P29/00; C07D265/22; C07D311/22; (IPC1-7): C07D265/22; A61K31/353; A61K31/536; A61P1/02; A61P1/04; A61P9/04; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P29/00; C07D311/22
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama