COCONJUGATE VACCINE COMPRISING IMMUNOGENIC PROTEIN, HIV RELATED PEPTIDE AND ANIONIC PART

Title:

COCONJUGATE VACCINE COMPRISING IMMUNOGENIC PROTEIN, HIV RELATED PEPTIDE AND ANIONIC PART

Document Type and Number:

Japanese Patent JPH0625300

Kind Code:

A

Abstract:

PURPOSE: To provide a coconjugate which is useful for inducing antipeptide immune response in mammals, for inducing HIVneutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or HIV disease including acquired immune deficiency syndrome(AIDS) or for treating humans suffering from HIV infection or diseases.

CONSTITUTION: This new coconjugate consists of an immunogenic protein or protein complex and has a first set of covalent linkages to low mol.wt. part-a- and a second set of covalent linkages. The low mol.wt. part-a- shows anionic or polyanionic property at physiological pH. The second set has the covalent linkages to a peptide comprising a human immunodeficiency virus(HIV) principal neutralizing determinant(PND) or a peptide immunologically equivalent to that.

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Inventors:

UIRIAMU JIEE REENZA
SUTEFUEN MARUBURUGU
RICHIYAADO ERU TORUMAN
EMIRIO EE EMINI

Application Number:

JP27168491A

Publication Date:

February 01, 1994

Filing Date:

July 19, 1991

Export Citation:

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Assignee:

MERCK & CO INC

International Classes:

A61K35/74; A61K35/76; A61K39/21; A61P31/12; A61P31/18; C07K1/113; C07K14/00; C07K14/155; C07K14/16; C07K14/195; C07K14/22; C07K14/41; C07K16/10; C07K16/12; C07K19/00; A61K38/00; A61K39/00; (IPC1-7): C07K15/12; A61K35/74; A61K39/21

Domestic Patent References:

JPS64500432A
JPH0222300A	1990-01-25
JPS61186400A	1986-08-20

Attorney, Agent or Firm:

Masao Okabe (6 others)

Next Patent: ESTER AND AMIDE OF SUBSTITUTED INDENYL ACETIC ACID