Title:
COMBINATION THERAPY TO TREAT HEPATITIS B VIRUS
Document Type and Number:
Japanese Patent JP2011079840
Kind Code:
A
Abstract:
To provide a method for treating human hepatitis B virus infection by combining or alternately administering synergistically effective amount of agents having already known to have anti-hepatitis B virus activity.
The method for treating human hepatitis B virus infection by administering FTC combined with penciclovir, famciclovir or Bis-POM-PMEA or alternately administering them is provided. The method for treating human hepatitis B virus infection by administering L-FMAU combined with penciclovir or Bis-POM-PMEA or alternately administering them, and the method by administering DAPD combined with Bis-POM-PMEA or alternately administering them are also provided.
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Inventors:
FURMAN PHILLIP A
PAINTER GEORGE R
BARRY DAVID
ROUSSEAU FRANCK
PAINTER GEORGE R
BARRY DAVID
ROUSSEAU FRANCK
Application Number:
JP2010252915A
Publication Date:
April 21, 2011
Filing Date:
November 11, 2010
Export Citation:
Assignee:
TRIANGLE PHARMACEUTICALS INC
International Classes:
A61K31/513; C07D473/16; A61K31/52; A61K31/522; A61K31/662; A61K31/675; A61K31/70; A61K45/06; A61P1/16; A61P31/12; A61P31/14; A61P31/20; A61P35/00; C07D411/04; C07D473/18; C07D473/32; C07D473/34
Other References:
JPN6010023800; ＭＡＲＱＵＥＳ，Ａ．Ｒ． ｅｔ ａｌ: 'Ａｄｖａｎｃｅｓ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｃｈｒｏｎｉｃ ｈｅｐａｔｉｔｉｓ Ｂ ｖｉｒｕｓ ｉｎｆｅｃｔｉｏｎ' Ｒｅｖ Ｍｅｄ Ｖｉｒｏｌ Ｖｏｌ．８， Ｎｏ．４, 199810, ｐ．２２３-２３４
JPN6010023802; ＫＯＲＢＡ，Ｂ．Ｅ．: 'Ｉｎ ｖｉｔｒｏ ｅｖａｌｕａｔｉｏｎ ｏｆ ｃｏｍｂｉｎａｔｉｏｎ ｔｈｅｒａｐｉｅｓ ａｇａｉｎｓｔ ｈｅｐａｔｉｔｉｓ Ｂ ｖｉｒｕｓ ｒｅｐｌｉｃａｔｉｏｎ' Ａｎｔｉｖｉｒａｌ Ｒｅｓ Ｖｏｌ．２９， Ｎｏ．１, 1996, ｐ．４９-５１
JPN6010023804; ＦＵＲＭＡＮ，Ｐ．Ａ． ｅｔ ａｌ: 'Ｔｈｅ ａｎｔｉ-ｈｅｐａｔｉｔｉｓ Ｂ ｖｉｒｕｓ ａｃｔｉｖｉｔｉｅｓ， ｃｙｔｏｔｏｘｉｃｉｔｉｅｓ， ａｎｄ ａｎａｂｏｌｉｃ ｐｒｏｆｉｌｅｓ ｏｆ ｔｈｅ （-） ａｎｄ （＋） ｅｎａｎ' Ａｎｔｉｍｉｃｒｏｂ Ａｇｅｎｔｓ Ｃｈｅｍｏｔｈｅｒ Ｖｏｌ．３６， Ｎｏ．１２, 1992, ｐ．２６８６-９２
JPN6010023807; ＤＥ，Ｃ．Ｌ．: 'Ｉｎ ｓｅａｒｃｈ ｏｆ ａ ｓｅｌｅｃｔｉｖｅ ａｎｔｉｖｉｒａｌ ｃｈｅｍｏｔｈｅｒａｐｙ' Ｃｌｉｎ Ｍｉｃｒｏｂｉｏｌ Ｒｅｖ Ｖｏｌ．１０， Ｎｏ．４, 1997, ｐ．６７４-９３
JPN6010023802; ＫＯＲＢＡ，Ｂ．Ｅ．: 'Ｉｎ ｖｉｔｒｏ ｅｖａｌｕａｔｉｏｎ ｏｆ ｃｏｍｂｉｎａｔｉｏｎ ｔｈｅｒａｐｉｅｓ ａｇａｉｎｓｔ ｈｅｐａｔｉｔｉｓ Ｂ ｖｉｒｕｓ ｒｅｐｌｉｃａｔｉｏｎ' Ａｎｔｉｖｉｒａｌ Ｒｅｓ Ｖｏｌ．２９， Ｎｏ．１, 1996, ｐ．４９-５１
JPN6010023804; ＦＵＲＭＡＮ，Ｐ．Ａ． ｅｔ ａｌ: 'Ｔｈｅ ａｎｔｉ-ｈｅｐａｔｉｔｉｓ Ｂ ｖｉｒｕｓ ａｃｔｉｖｉｔｉｅｓ， ｃｙｔｏｔｏｘｉｃｉｔｉｅｓ， ａｎｄ ａｎａｂｏｌｉｃ ｐｒｏｆｉｌｅｓ ｏｆ ｔｈｅ （-） ａｎｄ （＋） ｅｎａｎ' Ａｎｔｉｍｉｃｒｏｂ Ａｇｅｎｔｓ Ｃｈｅｍｏｔｈｅｒ Ｖｏｌ．３６， Ｎｏ．１２, 1992, ｐ．２６８６-９２
JPN6010023807; ＤＥ，Ｃ．Ｌ．: 'Ｉｎ ｓｅａｒｃｈ ｏｆ ａ ｓｅｌｅｃｔｉｖｅ ａｎｔｉｖｉｒａｌ ｃｈｅｍｏｔｈｅｒａｐｙ' Ｃｌｉｎ Ｍｉｃｒｏｂｉｏｌ Ｒｅｖ Ｖｏｌ．１０， Ｎｏ．４, 1997, ｐ．６７４-９３
Attorney, Agent or Firm:
Yoshio Kawaguchi
Katsuma Osaki
Katsuma Osaki