Title:
METHOD FOR FORMING SUBMICRON PARTICLE OF WATER-INSOLUBLE COMPOUND
Document Type and Number:
Japanese Patent JP2011079839
Kind Code:
A
Abstract:
To provide a high-productivity method for obtaining a suspension of a wide-range water-insoluble compound having biological applications.
The suspension is obtained by the following process: a microparticulate suspension of a water-insoluble compound, particularly of submicron particles of a drug, is stabilized with a surface modifier molecules; simultaneously, from a compressed solution of the compound and the surface modifier prepared by dissolving them in a liquefied gas, they are rapidly put to expansion injection into an aqueous medium to obtain the suspension. Optionally, in addition, the aqueous suspension thus prepared is homogenized with a high-pressure homogenizer.
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Inventors:
PACE GARY W
VACHON G MICHAEL
MISHRA AWADHESH K
HENRIKSEN INGE B
KRUKONIS VAL
GODINAS ANTHONY
VACHON G MICHAEL
MISHRA AWADHESH K
HENRIKSEN INGE B
KRUKONIS VAL
GODINAS ANTHONY
Application Number:
JP2010250097A
Publication Date:
April 21, 2011
Filing Date:
November 08, 2010
Export Citation:
Assignee:
OBAN ENERGY LTD
International Classes:
A61K9/10; A61K9/14; A61K9/16; A61K9/50; A61K9/51; A61K31/216; A61K31/57; A61K38/00; A61K47/24; A61K47/34; B01F3/12; B01J3/00
Domestic Patent References:
| JP2002511398A | 2002-04-16 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroaki Noya
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroaki Noya