Title:
受容体型チロシンキナーゼ阻害剤および血管新生阻害剤を用いる併用療法
Document Type and Number:
Japanese Patent JP4364510
Kind Code:
B2
Abstract:
The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of receptor tyrosine kinase antagonists/inhibitors, especially ErbB receptor antagonists, more preferably EGF receptor (Her 1) antagonists and anti-angiogenic agents, preferably integrin antagonists, optionally together with agents or therapy forms that have additive or synergistic efficacy when administered together with the combination of antagonists/inhibitors, such as chemotherapeutic agents and or radiation therapy. The therapy can result in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone.
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Inventors:
Gothman, Zimon
Kleish, Hans-Georg
Kleish, Hans-Georg
Application Number:
JP2002555839A
Publication Date:
November 18, 2009
Filing Date:
December 21, 2001
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K39/395; A61K31/337; A61K45/06; A61K31/704; A61K31/7064; A61K31/7068; A61K33/24; A61K38/00; A61K38/08; A61K41/00; A61K47/48; A61P35/00; A61P35/04; A61P43/00; C07K16/30
Domestic Patent References:
| JP5506157A | ||||
| JP9132593A |
Other References:
Clinical Cancer Research,2000年,Vol.6,No.5,p1936-1948
Clinical Cancer Research,2000年,Vol.6,No.12,p4874-4884
Cell,1994年,Vol.79,No.7,p1157-1164
Science,1995年,Vol.270,p1500-1502
Clinical Cancer Research,2000年,Vol.6,No.12,p4874-4884
Cell,1994年,Vol.79,No.7,p1157-1164
Science,1995年,Vol.270,p1500-1502
Attorney, Agent or Firm:
Akio Miyazaki
Ohta Kengaku
Ishibashi Masayuki
Masaaki Ogata
Ohta Kengaku
Ishibashi Masayuki
Masaaki Ogata