To provide a composition and a method for diagnosis and treatment of the growth and proliferation of tumor cells in mammals including human beings.
A gene to be amplified is identified in the genome of the tumor cell. The gene amplification relates to the excess expression of a gene product compared to a normal cell having the same tissue form, and it is predicted that the amplification contributes to tumor formation. As a result, the protein encoded by the amplified gene is considered to be useful for diagnosis and/or treatment (including prevention) of some kind of cancer, and acts so as to predict the prognosis of tumor treatment. The new polypeptide and the nucleic acid encoding the polypeptide are provided. The vector containing the nucleic acid sequence, the host cell, the chimera polypeptide molecule containing the polypeptide fused with a different kind of a polypeptide sequence, the antibody binding to the polypeptide, and the method for producing the polypeptide are also provided.
GODDARD AUDREY
GURNEY AUSTIN L
ROY MARGARET ANN
WATANABE COLIN K
WOOD WILLIAM I
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