Title:
細胞及び生物の寿命及びストレス応答を操作するための組成物
Document Type and Number:
Japanese Patent JP2007530417
Kind Code:
A
Abstract:
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
Inventors:
Sinclair, David, A.
Howitz, Conrad, Tee.
Zipkin, Robert, Yi.
Howitz, Conrad, Tee.
Zipkin, Robert, Yi.
Application Number:
JP2006518817A
Publication Date:
November 01, 2007
Filing Date:
July 01, 2004
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61K45/00; A61K31/00; A61K31/015; A61K31/05; A61K31/085; A61K31/09; A61K31/10; A61K31/12; A61K31/122; A61K31/133; A61K31/136; A61K31/15; A61K31/167; A61K31/175; A61K31/185; A61K31/222; A61K31/343; A61K31/353; A61K31/36; A61K31/37; A61K31/381; A61K31/4152; A61K31/4162; A61K31/4166; A61K31/4172; A61K31/42; A61K31/426; A61K31/428; A61K31/438; A61K31/4409; A61K31/455; A61K31/4709; A61K31/473; A61K31/4745; A61K31/496; A61K31/498; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61K31/549; A61K31/56; A61K31/57; A61K31/65; A61K31/6615; A61K31/7004; A61K31/7034; A61K36/87; A61K45/06; A61P1/16; A61P3/06; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/08; A61P17/00; A61P17/14; A61P17/16; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/12; A61P29/00; A61P31/10; A61P31/12; A61P31/16; A61P31/18; A61P31/22; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C12N1/16; C12N5/06; C12N9/16; C12Q1/02; C12Q1/34; C07C39/16; C07C39/21; C07C39/23; C07C39/373; C07C43/205; C07C43/23; C07C69/18; C07C205/20; C07C205/35; C07C233/25; C07C233/75; C07C235/56; C07C247/16; C07C323/18; C07C323/19; C07D213/74; C07D213/82; C07D217/26; C07D231/20; C07D233/70; C07D233/84; C07D241/42; C07D261/18; C07D263/34; C07D277/82; C07D307/84; C07D311/16; C07D311/32; C07D311/36; C07D311/60; C07D311/62; C07D311/66; C07D317/60; C07D333/60; C07D405/06; C07D405/12; C07D471/04; C07D475/08; C07D487/04; C07D491/052; C07D491/22; C07D493/04; C07D495/20; C07D498/06; C07D513/04; C07D513/14; C07H7/04; C07H15/203; C07J7/00; C07J19/00; C12N15/09
Domestic Patent References:
| JP2001048722A | 2001-02-20 | |||
| JP2002527389A | 2002-08-27 | |||
| JP2003137727A | 2003-05-14 |
Attorney, Agent or Firm:
Mizuno Yuuki
Junji Endo
Junji Endo