Title:
セリアックスプルー病を治療するための組成物および方法
Document Type and Number:
Japanese Patent JP7429907
Kind Code:
B2
Abstract:
Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
Inventors:
Pluto, ingrid, swanson
Wolf, clancy
Siegel, Justin, Bloomfield
Timber, Christine, Elaine
Stuart lance
Baker, David
Wolf, clancy
Siegel, Justin, Bloomfield
Timber, Christine, Elaine
Stuart lance
Baker, David
Application Number:
JP2021099361A
Publication Date:
February 09, 2024
Filing Date:
June 15, 2021
Export Citation:
Assignee:
University of Washington
The Regents of the University of California
The Regents of the University of California
International Classes:
C12N9/48; A61K35/12; A61K38/48; A61P1/04; A61P37/08; C07K14/00; C12N15/57
Domestic Patent References:
| JP2014529399A |
Foreign References:
| WO2015023728A1 |
Other References:
J Am Chem Soc. , 2012 Dec 19 (Epub 2012 Dec 5), vol. 134, no. 50, pp. 20513-20520
J Am Chem Soc. , 2015 Oct 14 (Epub 2015 Sep 29), vol. 137, no. 40, pp. 13106-13113,(supplementary information pp. S1-S9)
J Am Chem Soc. , 2015 Oct 14 (Epub 2015 Sep 29), vol. 137, no. 40, pp. 13106-13113,(supplementary information pp. S1-S9)
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Kamoto Takahashi
Nao Oda
Akiyo Iwahori
Kamoto Takahashi
Previous Patent: Wall panel mounting structure and reinforced earth wall construction method
Next Patent: optical device
Next Patent: optical device