COMPOUND INHIBITING RETROVIRUS PROTEASE

Japanese Patent JP3812969

B2

PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific molecular structure, exhibiting an action on the inhibition of a retrovirus protease, and useful for the therapy of retrovirus infection, especially human immunodeficiency virus(HIV) infection causing AIDS, etc. SOLUTION: A new compound of formula I [R1 is a mono-substituted (iso) thiazolyl, a mono-substituted (iso)oxazolyl; (n) is 1-3; R2, R6 are each H, a lower alkyl; R3 is a lower alkyl; R4, R4a are each a (substituted)phenyl, a (substituted) thiazolyl; R7 is a (substituted) (iso)thiazolyl, a (substituted) (iso)oxazolyl; X is H and Y is OH, or X is OH and Y is H, etc.; Z is absent, O, S, CH2, etc.,]. The compound of formula I is useful for the therapy of retrovirus infection, etc. The compound is obtained by reacting an amino group-containing compound of formula II with an N-substitute amino acid of formula III or its active ester derivative.