Title:
GABAAレセプター複合体と相互作用させるための化合物
Document Type and Number:
Japanese Patent JP4008024
Kind Code:
B2
Abstract:
Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3 alpha -hydroxy-5-reduced steroid derivatives.
More Like This:
Inventors:
Gee, Kelvin W.
Orchid, Nancy Tsusai-Con
Upasani, Rabindra Bee.
Hogen Gump, Dake Jay.
Paddy, robert
Bolger, Michael Bee.
Tahir, Hasan
Orchid, Nancy Tsusai-Con
Upasani, Rabindra Bee.
Hogen Gump, Dake Jay.
Paddy, robert
Bolger, Michael Bee.
Tahir, Hasan
Application Number:
JP50089295A
Publication Date:
November 14, 2007
Filing Date:
May 23, 1994
Export Citation:
Assignee:
PURDUE PHARMA L.P.
International Classes:
C07J5/00; A61K31/56; A61K31/565; A61K31/57; A61K31/573; A61K31/575; A61K31/58; A61K31/661; A61P25/00; A61P25/20; A61P43/00; C07J7/00; C07J17/00; C07J31/00; C07J33/00; C07J41/00; C07J43/00; C07J51/00
Foreign References:
| DE1046039B | ||||
| WO1993003732A1 | ||||
| WO1993005786A1 |
Other References:
The action of haloform on the steroid-carbonyl function, Chemical Abstracts, 53(9), 8201-8202 (1959)
MENDELSON, W.B., et al., Sleep induction by an adrenal steroid in the rat, Psychopharmacology, 93, pp.226-229 (1987)
BOWERS, B.J., et al., Biochemical and Behavioral Effects of Steroids on GABAA Receptor Function in Long-and Short-Sleep..., Brain Res. Bull., 29, pp.57-68 (1992)
MAJEWSKA, M.D., et al., Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor, Science, 232, pp.1004-1007 (1986)
ARAFAT, E.S., et al., Sedative and hypnotic effects of oral administration of micronized progesterone may be madiated..., Am. J. Obstet Gynecol., 159, pp.1203-1209 (1988)
MELCHIOR, C.L., et al., Interaction of Pregnanolone and Pregnenolone Sulfate With Ethanol and Pentobarbital, Pharmacol. Biochem. Behavior, 42, pp.605-611 (1992)
GYERMEK, L., Pregnanolone: A Highly Potnt, Naturally Occuring Hypnotic-Anesthetic Agent, Proc. Soc. Exp. Biol. Med., 125, pp.1058-1062 (1967)
SOYKA, L.F., et al., DISTRIBUTION AND HEPATIC AND HEPATIC METABOLISM OF PREGNANOLONE IN THE RAT, Biochem. Pharmacol., 21, pp.657-671 (1972)
MENDELSON, W.B., et al., Sleep induction by an adrenal steroid in the rat, Psychopharmacology, 93, pp.226-229 (1987)
BOWERS, B.J., et al., Biochemical and Behavioral Effects of Steroids on GABAA Receptor Function in Long-and Short-Sleep..., Brain Res. Bull., 29, pp.57-68 (1992)
MAJEWSKA, M.D., et al., Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor, Science, 232, pp.1004-1007 (1986)
ARAFAT, E.S., et al., Sedative and hypnotic effects of oral administration of micronized progesterone may be madiated..., Am. J. Obstet Gynecol., 159, pp.1203-1209 (1988)
MELCHIOR, C.L., et al., Interaction of Pregnanolone and Pregnenolone Sulfate With Ethanol and Pentobarbital, Pharmacol. Biochem. Behavior, 42, pp.605-611 (1992)
GYERMEK, L., Pregnanolone: A Highly Potnt, Naturally Occuring Hypnotic-Anesthetic Agent, Proc. Soc. Exp. Biol. Med., 125, pp.1058-1062 (1967)
SOYKA, L.F., et al., DISTRIBUTION AND HEPATIC AND HEPATIC METABOLISM OF PREGNANOLONE IN THE RAT, Biochem. Pharmacol., 21, pp.657-671 (1972)
Attorney, Agent or Firm:
Kazuo Sato
Onodera Kyohiro
Konno Akio
Onodera Kyohiro
Konno Akio