Title:
化合物並びに細胞増殖性疾患、網膜症及び関節炎を処置する方法
Document Type and Number:
Japanese Patent JP4648894
Kind Code:
B2
Abstract:
Quinoline derivatives (I) and their tautomers, optical and geometrical isomers, racemates, salts, hydrates or mixtures are new. Quinoline derivatives of formula (I) and their tautomers, optical and geometrical isomers, racemates, salts, hydrates or mixtures are new. [Image] R 1pyran derivative of formula (a1), piperdine derivative of formula (a2), dihydropyrrole derivative of formula (a3), alkane derivative of formula (a4) or amine derivative of formula (a5); R 2H, 3-6C alkyl or 3-6C alkenyl; B : halo, preferably chlorine, hydroxyl, O-CH 2-O-CH 3(MOM), O-CH 2-O-CH 2-CH 2-O-CH 3(MEM), OSO 2-alkyl or OSi(CH 3) 2tBu; D : O, NR 3, CR'R'' or S; X, Y : O, S or a radical NR 4; R 3H, alkyl, carboxylate, acyl, carboxamide or SO 2-alkyl; R', R'' : H or alkyl radical; R 4H, 1-10C alkyl, aryl or aralkyl; linker : (CH 2) n; n : 1-10; (optionally interrupted by an heteroatom (preferably N, O , S and P) or a carbonyl group, or an aryldialkyl (preferably xylenyl); and A : quinoline derivative of formulae (a6-a7), benzopyrimidine derivative of formula (a8) or benzothiophene derivative of formula (a9) (all optionally substituted). [Image] ACTIVITY : Cytostatic; Antiangiogenic; Vasotropic; Antiarthritic; Antidiabetic; Ophthalmological. MECHANISM OF ACTION : None given.
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Inventors:
Lubron, Bertrand
Petit, Sylvert
Picard, Virginie
Taverne, Thierry
Schwaig Hoffer, Fabian
Petit, Sylvert
Picard, Virginie
Taverne, Thierry
Schwaig Hoffer, Fabian
Application Number:
JP2006502497A
Publication Date:
March 09, 2011
Filing Date:
February 27, 2004
Export Citation:
Assignee:
EXONHIT THERAPEUTICS SA
International Classes:
C07D405/12; A61K31/351; A61K31/381; A61K31/4709; A61K31/496; A61K31/517; A61K31/5377; A61K31/541; A61P3/10; A61P9/10; A61P19/02; A61P27/02; A61P35/00; A61P35/02; C07D405/14; C07D409/14; C07D411/12
Domestic Patent References:
| JP2005529079A | ||||
| JP62174057A |
Foreign References:
| US4812584 | ||||
| US4644071 |
Other References:
スロバキア特許発明明細書第278075号(SK 278075 B6),1995年12月 6日
YAMATO,M. et al,Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives,J Med Chem,1987年,Vol.30, No.10,p.1897-900
Miroslav Veverka and Eva Kralovicova,,Synthesis of some biologically active derivatives of 2-hydroxymethyl-5-hydroxy-4H-pyran-4-one,Collection of Czechoslovak Chemical Communications,1990年,Vol.55,No.3,pp.833-840
YAMATO,M. et al,Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives,J Med Chem,1987年,Vol.30, No.10,p.1897-900
Miroslav Veverka and Eva Kralovicova,,Synthesis of some biologically active derivatives of 2-hydroxymethyl-5-hydroxy-4H-pyran-4-one,Collection of Czechoslovak Chemical Communications,1990年,Vol.55,No.3,pp.833-840
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda