CONDENSED BENZAMIDE, PRODUCTION THEREOF AND 5-LIPOXYGENASE INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT

Japanese Patent JPS62230760

A

NEW MATERIAL:A compound shown by formula I [A is single bond, vinylene which may be replaced with 1W4C alkyl, ethylene, etc.; B is group shown by formula II, formula III, etc.,; n is 7 or 8; R1 is carboxyl or 5-tetrazolyl; R2 is H or 1W4C alkyl; R3 is H, halogen or 1W4C alkyl; dotted line part is double or triple bond.

EXAMPLE: 8-[N-(2E, 11Z, 14Z)-Eicosa-2, 11, 14-trienoyl]-N-methylami-no-]-2-(5- tetrazolyl)-1,4-benzdioxane.

USE: A 5-lipoxygenase inhibitor useful for remedying and preventing various allergic diseases caused by leukotriene.

PREPARATION: A carboxylic acid shown by formula IV is reacted with an amine shown by formula V (R10 is carboxy, 2W5C alkoxycarbonyl, etc.) and optionally saponified to give a compound shown by formula I.

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ARAI YOSHINOBU
NAKAI HISAO
TODA MASAAKI

JP7103386A

October 09, 1987

March 31, 1986

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ONO PHARMACEUTICAL CO

C07D257/04; A61K31/195; A61K31/335; A61K31/357; A61K31/47; A61P37/08; A61P43/00; C07C67/00; C07C231/00; C07C231/02; C07C231/12; C07C233/55; C07C235/56; C07C313/00; C07C319/20; C07C323/62; C07D209/42; C07D215/00; C07D215/48; C07D257/00; C07D307/00; C07D307/84; C07D311/00; C07D311/22; C07D319/00; C07D319/18; C07D401/04; C07D405/04; C12N9/99; (IPC1-7): A61K31/195; A61K31/335; A61K31/47; C07/; C07C103/66; C07C103/84; C07C148/00; C07C149/41; C07D209/42; C07D215/00; C07D215/48; C07D257/00; C07D257/04; C07D307/00; C07D307/84; C07D311/00; C07D311/22; C07D319/00; C07D319/18; C07D401/04; C07D405/04; C12N9/99

Kunihisa Oya

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