Title:
CONDENSED PYRAZOLE DERIVATIVE
Document Type and Number:
Japanese Patent JP2001220390
Kind Code:
A
Abstract:
To provide a calcium-release dependent calcium channel inhibitor containing an N-phenyl-condensed pyrazole derivative or its pharmacologically permissible salt useful as an IL-2 formation inhibiting agent or an agent for the prevention or treatment of allergic, inflammatory or autoimmune diseases.
This invention discloses a condensed pyrazole derivative expressed by general formula (1) [one of Ra and Rc is H, a lower alkyl, a lower alkenly or the like; the other one of Ra and Rc forms together with Rb a 3-6C alkylene chain or alkenylene chain which may be interrupted with NRd to form a condensed ring with the adjacent pyrazole ring; B is a (substituted) phenylene; and A is a (substituted) aryl or a (substituted) monocyclic or bicyclic heteroaryl] and its pharmacologically permissible salt.
Inventors:
KUBOTA KOICHI
YONETOKU YASUHIRO
OKAMOTO YOSHINORI
ISHIKAWA ATSUSHI
TAKEUCHI MAKOTO
Application Number:
JP2000031493A
Publication Date:
August 14, 2001
Filing Date:
February 09, 2000
Assignee:
YAMANOUCHI PHARMA CO LTD
International Classes:
C07D231/54; A61K31/416; A61K31/422; A61K31/4245; A61K31/427; A61K31/436; A61K31/437; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/4545; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D231/56; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12; C07D471/04; C07D491/113; (IPC1-7): C07D401/12; A61K31/416; A61K31/422; A61K31/4245; A61K31/427; A61K31/436; A61K31/437; A61K31/4439; A61K31/4545; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D231/54; C07D231/56; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12; C07D471/04; C07D491/113
Attorney, Agent or Firm:
Shozo Nagai (2 outside)
