Title:
抗炎症作用を有するコンジュゲート
Document Type and Number:
Japanese Patent JP2008517993
Kind Code:
A
Abstract:
The present invention relates to new compounds represented by Formula I:
wherein M represents a macrolide subunit of the substructure VIII:
L represents the chain of the substructure IX or XIII:
-X 1 -(CH 2 ) m -Q-(CH 2 ) n -X 2 -IX
-X 1 -(CH 2 ) m -V-(CH 2 ) p -Q-(CH 2 ) n -X 1 -XIII
Z represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.
Inventors:
Muraden Mercep
Milan Mesic
Linda Tomaskovic
Stribol Markovic
Visnia polyak
Goldana Sheyan
Cell Villa Sermani
Milan Mesic
Linda Tomaskovic
Stribol Markovic
Visnia polyak
Goldana Sheyan
Cell Villa Sermani
Application Number:
JP2007538531A
Publication Date:
May 29, 2008
Filing Date:
October 27, 2005
Export Citation:
Assignee:
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.
International Classes:
C07D267/00; A61K31/395; A61K31/4155; A61K31/4427; A61K31/567; A61P1/00; A61P9/00; A61P11/00; A61P11/06; A61P17/06; A61P29/00; A61P31/04; A61P37/02; A61P43/00; C07D413/12; C07J43/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita