Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
CONTROLLED DISSOLUTION CROSSLINKED PROTEIN CRYSTAL
Document Type and Number:
Japanese Patent JP2008283976
Kind Code:
A
Abstract:

To provide a crosslinked protein crystal characterized by the ability to change from an insoluble and stable form to a soluble and active form by the environmental change of the crystal.

Provided is the crosslinked protein crystal characterized by the ability to change from an insoluble and stable form to a soluble and active form by the environmental change of the crystals. The change is selected from the group consisting of change in temperature, change in pH, change in chemical composition, change from a concentrate form to a dilute form, change in oxidation-reduction potential of the solution, change in the incident radiation, change in transition metal concentration, change in fluoride concentration, change in free radical concentration, change in metal chelating agent concentration, change in shear force acting upon the crystals and combinations thereof.


Inventors:
MARGOLIN ALEXEY L
PERSICHETTI ROSE A
ST CLAIR NANCY L
KHALAF NAZER K
SHENOY BHAMI C
Application Number:
JP2008148661A
Publication Date:
November 27, 2008
Filing Date:
June 05, 2008
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ALTUS PHARMACEUTICALS INC
International Classes:
C12N9/20; C12N9/54; A23K1/16; A61K8/35; A61K8/36; A61K8/42; A61K8/46; A61K8/64; A61K8/66; A61K8/72; A61K9/22; A61K38/00; A61K38/22; A61K38/27; A61K38/43; A61K38/44; A61K38/51; A61K38/52; A61K38/53; A61K39/395; A61P31/12; A61P43/00; A61Q5/02; A61Q19/00; C07K1/14; C07K14/765; C11D3/37; C11D3/386; C11D17/00; C12N9/56; C12N9/92; C12N11/00; C12N11/04; C12S99/00; C30B29/58
Domestic Patent References:
JPS62186791A1987-08-15
Attorney, Agent or Firm:
Hidesaku Yamamoto