Title:
CONTROLLED-RELEASE COMPOSITION CONTAINING OPIOID AGONIST AND ANTAGONIST
Document Type and Number:
Japanese Patent JP2014169306
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To urge approval of a patient, and thereby to increase effects of opioid agonist treatment of a patient to be treated with the opioid agonist.SOLUTION: Controlled-release dosage forms containing: an opioid agonist; an opioid antagonist; and a controlled release material release during a dosing interval an analgesic or sub-analgesic amount of the opioid agonist along with an amount of the opioid antagonist effective to attenuate a side effect of the opioid agonist. The dosage form provides analgesia for at least about 8 hours when administered to human patients. In other embodiments, the dose of antagonist released during the dosing interval enhances the analgesic potency of the opioid agonist.
Inventors:
OSHLACK BENJAMIN
CURTIS WRIGHT
CURTIS WRIGHT
Application Number:
JP2014094376A
Publication Date:
September 18, 2014
Filing Date:
May 01, 2014
Export Citation:
Assignee:
EURO CELTIQUE SA
International Classes:
A61K9/08; A61K9/00; A61K45/08; A61K9/02; A61K9/10; A61K9/14; A61K9/16; A61K9/20; A61K9/22; A61K9/26; A61K9/28; A61K9/48; A61K9/50; A61K9/52; A61K9/54; A61K9/58; A61K9/70; A61K31/135; A61K31/137; A61K31/439; A61K31/4468; A61K31/451; A61K31/46; A61K31/485; A61K38/00; A61K38/22; A61K45/06; A61K47/02; A61K47/14; A61K47/26; A61K47/32; A61K47/38; A61P25/04; A61P39/00; A61P43/00
Domestic Patent References:
| JPH07503481A | 1995-04-13 | |||
| JPH01279895A | 1989-11-10 | |||
| JPH0597806A | 1993-04-20 |
Foreign References:
| WO1999032119A1 | 1999-07-01 | |||
| WO1999061003A1 | 1999-12-02 | |||
| US5767125A | 1998-06-16 | |||
| WO1998025613A2 | 1998-06-18 |
Other References:
ANESTHESIOLOGY, vol. Vol.87, JPN6016041451, 1997, pages 1075 - 81
Attorney, Agent or Firm:
Kobayashi 浩
Norio Omori
Sugiyama 共永
Yasuhito Suzuki
Norio Omori
Sugiyama 共永
Yasuhito Suzuki