Title:
冷感剤及びTRPM8活性化剤
Document Type and Number:
Japanese Patent JP5528524
Kind Code:
B2
Abstract:
Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1):
wherein R 1 represents a hydrogen atom; R 2 represents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; R 3 represents a hydrogen atom or a hydroxyl group; R 4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; R 5 represents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and R 6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.
More Like This:
Inventors:
Toshihiro Shirai
Hiroshi Kusunoki
Sakai Mitsuyoshi
Kentaro Kumihashi
Hiroshi Kusunoki
Sakai Mitsuyoshi
Kentaro Kumihashi
Application Number:
JP2012253512A
Publication Date:
June 25, 2014
Filing Date:
November 19, 2012
Export Citation:
Assignee:
Kao Corporation
International Classes:
C09K3/00; A61K8/34; C07C43/23
Domestic Patent References:
| JP2010530413A | ||||
| JP2007261993A |
Foreign References:
| WO2012098281A1 |
Other References:
Kawamoto, Haruo,Pyrolytic cleavage mechanisms of lignin-ether linkages: a study on p-substituted dimers and trimers,Holzforschung,2008年,62(1),50-56
Sakai, Kokki,Cleavage of the β-O-4 bonds in lignin model compounds by an alcohol-bisulfite treatment,Mokuzai Gakkaishi,1990年,36(7),553-8
Zanarotti, Antonio,Synthesis and reactivity of lignin model quinone methides. Biomimetic synthesis of 8.0.4' neolignan,Journal of Chemical Research, Synopses,1983年,(12),306-7
Sakai, Kokki,Cleavage of the β-O-4 bonds in lignin model compounds by an alcohol-bisulfite treatment,Mokuzai Gakkaishi,1990年,36(7),553-8
Zanarotti, Antonio,Synthesis and reactivity of lignin model quinone methides. Biomimetic synthesis of 8.0.4' neolignan,Journal of Chemical Research, Synopses,1983年,(12),306-7
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto