Title:
CORRECTION-TYPE PLASMINOGEN ACTIVATOR
Document Type and Number:
Japanese Patent JPH01132377
Kind Code:
A
Abstract:
A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a fibronectin finger-like domain F, a sequence of two K2 kringle regions and a serine protease region SP, wherein the first of said kringles is free of any glycosylation site and the second of said kringles has a single glycosylation site.
Inventors:
REZURII DEBITSUTO BERU
AANESUTO JIEI MEIYAA
MAAKU ORIBAA PARUMIAA
HANIFUE EZAA TORUNEI
TOOMASU JIYOOJI UOOREN
TSUEECHIEIN WAN
AANESUTO JIEI MEIYAA
MAAKU ORIBAA PARUMIAA
HANIFUE EZAA TORUNEI
TOOMASU JIYOOJI UOOREN
TSUEECHIEIN WAN
Application Number:
JP25366088A
Publication Date:
May 24, 1989
Filing Date:
October 07, 1988
Export Citation:
Assignee:
MONSANTO CO
International Classes:
A61K38/46; A61P7/02; C12N5/00; C12N5/10; C12N9/64; C12N9/72; C12N15/09; C12N15/12; C12P21/02; A61K38/00; C12R1/91; (IPC1-7): A61K37/54; C12N5/00; C12N9/64; C12N15/00; C12P21/02
Attorney, Agent or Firm:
Akira Asamura (3 outside)
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