Title:
Cyclic amide as METAP-2 inhibitor
Document Type and Number:
Japanese Patent JP6273258
Kind Code:
B2
Abstract:
Compounds of the formula (I), in which R1, R3, R5, R6, R7, R, X and Y have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
Inventors:
Heinrich, Timo
Zenke, frank
Criere, Mireille
Frize-Hamim, Manja
Sini Sammy, Jayapura Sinarayanan
Zenke, frank
Criere, Mireille
Frize-Hamim, Manja
Sini Sammy, Jayapura Sinarayanan
Application Number:
JP2015503778A
Publication Date:
January 31, 2018
Filing Date:
March 21, 2013
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D207/12; A61K31/402; A61K31/4025; A61K31/403; A61K31/404; A61K31/407; A61K31/4155; A61K31/416; A61K31/4178; A61K31/4184; A61K31/4245; A61K31/428; A61K31/437; A61K31/4375; A61K31/438; A61K31/4439; A61K31/445; A61K31/45; A61K31/451; A61K31/454; A61K31/455; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/5377; A61K31/5383; A61K31/541; A61K31/55; A61K31/635; A61K45/00; A61P1/02; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P33/06; A61P35/00; A61P35/02; A61P35/04; A61P37/06; A61P37/08; A61P43/00; C07D207/16; C07D207/273; C07D211/42; C07D211/60; C07D211/76; C07D211/78; C07D223/10; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/12; C07D403/14; C07D405/04; C07D405/06; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/06; C07D471/04; C07D471/10; C07D491/107; C07D498/04
Domestic Patent References:
| JP63208590A | ||||
| JP2006513995A | ||||
| JP2010523646A | ||||
| JP2008502689A | ||||
| JP2005511478A | ||||
| JP2003500392A | ||||
| JP1226883A | ||||
| JP60163861A | ||||
| JP5931885B2 | ||||
| JP2011527295A |
Foreign References:
| WO2012033956A1 |
Other References:
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,2011年,47(7),1091-1096
Journal of Organic Chemistry,2010年,75(9),3085-3096
Tetrahedron Letters,2008年,49(41),5976-5979
Organic Letters,2001年,3(2),201-203
Synthesis,1997年,(2),191-194
Organic & Biomolecular Chemistry,2008年,6(14),2587-2595
Helvetica Chimica Acta,1969年,52(4),1134-45
Journal of Organic Chemistry,2010年,75(9),3085-3096
Tetrahedron Letters,2008年,49(41),5976-5979
Organic Letters,2001年,3(2),201-203
Synthesis,1997年,(2),191-194
Organic & Biomolecular Chemistry,2008年,6(14),2587-2595
Helvetica Chimica Acta,1969年,52(4),1134-45
Attorney, Agent or Firm:
Kiyoji Kuzuwa