Title:
CYCLIC AMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP3892187
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound exhibiting potent and selective cathepsin K inhibitory action and also useful as a done resorption inhibitor effective when orally administered.
SOLUTION: This new compound is a compound of formula I [R1 is a substituted alkyl or the like; ring A is a 5-7C saturated cyclic alkyl or the like; R2 is a (substituted) alkyl or the like; R3 is H or the like; R5 and R6 are each a (substituted) heterocyclic ring or the like], e.g. N-[(S)-1,2-dioxo-1-N-(2- methyl-2-propyl)amino-3-heptyl]-1-[N-(morpholine-4-carbonyl) amino]cyclohexanecarboxamide. The compound of formula I is obtained, for example, by reaction between a compound of formula II {e.g. 1-[N-(morpholine-4- carbonyl)amino]cyclohexanecarboxylic acid} and a compound of formula III [e.g. (3S)-N-(2-methyl-2-propyl)-3-amino-2-hydroxyheptanamide] in the presence of a condensation agent in an inert solvent followed by oxidation of the reaction product.
Inventors:
Akihiko Hosoda
Nobuo Kobayashi
Naoko Tanabe
Tsuneo Koji
Masahiro Shibata
Akihiro Sekine
Dozen Kimi
Nobuo Kobayashi
Naoko Tanabe
Tsuneo Koji
Masahiro Shibata
Akihiro Sekine
Dozen Kimi
Application Number:
JP31331999A
Publication Date:
March 14, 2007
Filing Date:
November 04, 1999
Export Citation:
Assignee:
Seikagaku Corporation
International Classes:
C07C271/24; C07D295/20; A61K31/16; A61K31/18; A61K31/27; A61K31/357; A61K31/36; A61K31/4406; A61K31/445; A61K31/47; A61K31/495; A61K31/5355; A61K31/5375; A61K31/54; A61K31/63; A61K38/00; A61P19/02; A61P19/08; A61P19/10; C07C311/20; C07C311/29; C07C311/46; C07C317/44; C07C323/60; C07D211/36; C07D213/71; C07D213/75; C07D215/36; C07D231/40; C07D277/20; C07D277/44; C07D307/14; C07D307/33; C07D307/52; C07D317/68; C07K5/065; (IPC1-7): C07C271/24; A61K31/16; A61K31/18; A61K31/27; A61K31/36; A61K31/4406; A61K31/445; A61K31/47; A61K31/495; A61K31/5355; A61K31/5375; A61K31/54; A61K31/63; A61K38/00; A61P19/02; A61P19/08; A61P19/10; C07C311/20; C07C311/29; C07C311/46; C07C317/44; C07C323/60; C07D211/36; C07D213/71; C07D213/75; C07D215/36; C07D231/40; C07D277/44; C07D295/20; C07D307/14; C07D307/33; C07D307/52; C07D317/68; C07K5/065
Domestic Patent References:
| JP2001525804A | ||||
| JP2000500742A |
Foreign References:
| WO1998001133A1 |
Attorney, Agent or Firm:
Fusayuki Saito
Keiko Ozawa
Hajime Tsukuni
Fumio Shinoda
Keiko Ozawa
Hajime Tsukuni
Fumio Shinoda