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Title:
CYCLIC ETHER AMIDE COMPOUND
Document Type and Number:
Japanese Patent JP2008162953
Kind Code:
A
Abstract:

To provide a new cyclic ether amide lipid constructing molecular aggregates by self-organization, and a lipid membrane forming a moderate intramolecular hydrogen bond.

This new cyclic ether amide lipid of 2 glycerol derivatives and 2 long chain alkyl compounds, having a diether bond backbone and an amide bond backbone simultaneously is obtained by synthesizing a diether lipid of a glycerol derivative building-in asymmetric groups and the long chain alkyl compound and then passing through a new intermediate material obtained by introducing an azide group having high reactivity. The obtained cyclic ether amide lipid is provided by forming the molecular aggregates by the self-organization, having a property close to that of a cyclic amide lipid and forming a lipid membrane having a somewhat weakened intramolecular hydrogen bond.


Inventors:
SHIBAUE MOTONARI
MIYOSHI SHIN
Application Number:
JP2006355091A
Publication Date:
July 17, 2008
Filing Date:
December 28, 2006
Export Citation:
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Assignee:
NAT INST OF ADV IND & TECHNOL
International Classes:
C07D273/08; C07C233/20; C07C247/04; C09K23/42; A61K9/127; A61K47/22
Domestic Patent References:
JP2004196703A2004-07-15
JP2003286281A2003-10-10
JP2005060326A2005-03-10
JP2004075586A2004-03-11