Title:
ノノムラエ種からの環状ペプチド、その生産プロセス、およびそれを含むマイコバクテリア関連疾病の治療または予防のための薬学的組成物
Document Type and Number:
Japanese Patent JP5756227
Kind Code:
B2
Abstract:
The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
Inventors:
Kim, woo
Ri, Sunwook
Park, san gin
Su, Jo Won
Re-in
Yoon, Temi
Choi, John Kung
Li, Jean
Kim, Jin Young
Jin, Yun Yu
Franz Blau, Scott
Cho, San Yun
Gao, Way
Paoli, Guido
McAlpine, James
Jose, Napolitano
Yerky, Birgiet
Friesen, brent
Rodriguez Brasco, Maria Florencia
Rankin, David
Ri, Sunwook
Park, san gin
Su, Jo Won
Re-in
Yoon, Temi
Choi, John Kung
Li, Jean
Kim, Jin Young
Jin, Yun Yu
Franz Blau, Scott
Cho, San Yun
Gao, Way
Paoli, Guido
McAlpine, James
Jose, Napolitano
Yerky, Birgiet
Friesen, brent
Rodriguez Brasco, Maria Florencia
Rankin, David
Application Number:
JP2014506323A
Publication Date:
July 29, 2015
Filing Date:
April 18, 2012
Export Citation:
Assignee:
LSIS CO.,LTD.
The, Board, Of, Trusties, Of, The, University, Of, Illinois
The, Board, Of, Trusties, Of, The, University, Of, Illinois
International Classes:
C07K7/64; A61K38/00; A61K45/00; A61P31/06; C07K1/16
Domestic Patent References:
| JP2010513512A |
Foreign References:
| WO2009119710A1 |
Other References:
Bioorg. Med. Chem. Lett. (2008) Vol.18, No.24, pp.6321-6323
J. Org. Chem. (2013) Vol.78, No.24, pp.12321-12329
J. Org. Chem. (2013) Vol.78, No.24, pp.12321-12329
Attorney, Agent or Firm:
Shinei Patent Office
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