Title:
ケモカイン受容体活性のシクロヘキセニルモジュレーター
Document Type and Number:
Japanese Patent JP2011528358
Kind Code:
A
Abstract:
The present application describes modulators of MCP-1 or CCR-2 of formula (I), or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I), are disclosed.
Inventors:
Percy H Carter
Gregory Di Brown
George V. de Lucca
Douglas G Butt
Louis-Kin Liu
Feng Kiu
Gregory Di Brown
George V. de Lucca
Douglas G Butt
Louis-Kin Liu
Feng Kiu
Application Number:
JP2011518827A
Publication Date:
November 17, 2011
Filing Date:
July 14, 2009
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07C61/39; A61K31/18; A61K31/192; A61P1/04; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07C61/40; C07C62/32; C07C62/34; C07C62/38; C07C311/06
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka