Title:
シトシン類似体、シトシン類似体の調製方法、DNAメチルトランスフェラーゼ1阻害剤、DNAメチル化の阻害方法、正常なDNAメチル化からの逸脱と関連する疾患の治療における類似体の使用
Document Type and Number:
Japanese Patent JP2013522289
Kind Code:
A
Abstract:
A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N4, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula where R1 is H, R3, R4, 2′-deoxyribosyl, R4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R5 and R6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.
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Inventors:
Balchshevsky, Yang
Markiewitz, Voichev, Tee
Adamska, Everina
Plitter, Beata
Guiller-Pietrask, Maugajata
Vishko, Eliza
Markiewitz, Maria
Fedork-Vishomirska, Agnieszka
Klinsky, Tadeusz
Fumi Elevsky, Martin
Markiewitz, Voichev, Tee
Adamska, Everina
Plitter, Beata
Guiller-Pietrask, Maugajata
Vishko, Eliza
Markiewitz, Maria
Fedork-Vishomirska, Agnieszka
Klinsky, Tadeusz
Fumi Elevsky, Martin
Application Number:
JP2013500020A
Publication Date:
June 13, 2013
Filing Date:
March 17, 2011
Export Citation:
Assignee:
Institut Kemi Bioorgani Tuney Piayenne
International Classes:
C07D239/47; A61K31/513; A61K31/7068; A61P35/00; A61P43/00; C07D401/12; C07D405/12; C07H19/073
Attorney, Agent or Firm:
Masaki Yamakawa
Shigeki Yamakawa
Shigeki Yamakawa