Title:
DERIVATIVE OF SPHINGOSINE
Document Type and Number:
Japanese Patent JP2001213858
Kind Code:
A
Abstract:
To provide a new compound having a sphingomyelinase antagonism.
This compound is a derivative of sphingosine or its pharmaceutically permissible salt expressed by general formula I [R1 is H, a 2-20C alkanoyl, benzoyl or the like, R2 is H, a 1-8C alkyl, -(CH2)nR5 (R5 is hydroxyl, an amino, a pyridyl, a pyrazyl, a morpholinyl, a thiazolyl, a tetrazolyl or the like, n is an integer of 0-5) or SOmR6 (R6 is phenyl or a substituted phenyl substituted with a halogen, a 1-5C alkyl, hydroxyl, an amino, an ureide group or the like, m is 0, 1 or 2.), Z is NR7 (R7 is H, hydroxyl or a 1-5C alkyl), Y is oxygen or NR8 (R8 is H or hydroxyl or a 1-5C alkyl), W is oxygen or sulfur, k is an integer of 1-20].
Inventors:
KOBORI TAKEO
SUGIMOTO KIKUO
AIDA KENICHI
TAGUCHI MINORU
SUGIMOTO KIKUO
AIDA KENICHI
TAGUCHI MINORU
Application Number:
JP2000355117A
Publication Date:
August 07, 2001
Filing Date:
November 22, 2000
Export Citation:
Assignee:
SAGAMI CHEM RES
TAISHO PHARMACEUTICAL CO LTD
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61K31/17; A61K31/192; A61K31/235; A61K31/27; A61K31/275; A61K31/41; A61K31/416; A61K31/4164; A61K31/426; A61K31/433; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/47; A61K31/4965; A61K31/5375; A61P3/04; A61P3/10; A61P9/10; A61P13/12; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C271/12; C07C271/16; C07C271/18; C07C271/20; C07C271/22; C07C271/28; C07C275/20; C07C275/42; C07C311/53; C07C323/43; C07D213/36; C07D213/75; C07D215/38; C07D231/56; C07D233/64; C07D241/20; C07D257/04; C07D277/20; C07D277/48; C07D295/12; C07D285/135; (IPC1-7): C07C271/12; A61K31/17; A61K31/192; A61K31/235; A61K31/27; A61K31/275; A61K31/41; A61K31/416; A61K31/4164; A61K31/426; A61K31/433; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/47; A61K31/4965; A61K31/5375; A61P3/04; A61P3/10; A61P9/10; A61P13/12; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C271/16; C07C271/18; C07C271/20; C07C271/22; C07C271/28; C07C275/20; C07C275/42; C07C311/53; C07C323/43; C07D213/36; C07D213/75; C07D215/38; C07D231/56; C07D233/64; C07D241/20; C07D257/04; C07D277/48; C07D285/135; C07D295/12
Attorney, Agent or Firm:
Kitagawa Fuzo
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