Title:
【発明の名称】生物学的利用率が向上し、個人間及び個人内の吸収偏差が狭められたイトラコナゾール含有組成物
Document Type and Number:
Japanese Patent JP2003516354
Kind Code:
A
Abstract:
The present invention relates to agent containing itraconazole - with both improved bioavailability, due to higher water-solubility and impressively reduced difference of pH-dependent solubility, and narrow intra- and inter-individual variation of its absorption- and a manufacturing method thereof. Agent containing itraconazole of the present invention consists of itraconazole, water-soluble macromolecule of 10-100 % w/w to itracotazole, solubilizing agent of 0.1-100 % w/w to itraconazole and pharmaceutically allowed additives. Agent containing itraconazole of the present invention minimizes absorption variation by dozing time after food intake as well as is available for adults with hypoacidity, AIDS patients and normal people. In addition, the manufacturing method introduces the elementary process, the spray drying, thereby control of physical properties of particles containing drug is easier and economy/production is improved.
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Inventors:
Won Jung-Won
Kim Jun-Han
Won Han-Sik
Jan Sun-War
Fly Warn-Taku
Kim Jun-Han
Won Han-Sik
Jan Sun-War
Fly Warn-Taku
Application Number:
JP2001543110A
Publication Date:
May 13, 2003
Filing Date:
December 31, 1999
Export Citation:
Assignee:
Don A Farm Company Limited
International Classes:
A61K9/06; A61K9/10; A61K9/12; A61K9/14; A61K9/16; A61K9/20; A61K9/30; A61K9/48; A61K31/4196; A61K31/495; A61K47/14; A61K47/18; A61K47/20; A61K47/30; A61K47/32; A61K47/34; A61K47/38; A61P31/10; (IPC1-7): A61K31/4196; A61K9/06; A61K9/10; A61K9/12; A61K9/14; A61K9/20; A61K9/30; A61K9/48; A61K47/14; A61K47/18; A61K47/20; A61K47/30; A61K47/32; A61K47/34; A61K47/38; A61P31/10
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)