Title:
【発明の名称】抗菌剤としての置換された3-ピロリジニルチオ-カルバペネム化合物
Document Type and Number:
Japanese Patent JP3367104
Kind Code:
B2
Abstract:
PCT No. PCT/JP93/00469 Sec. 371 Date Sep. 21, 1994 Sec. 102(e) Date Sep. 21, 1994 PCT Filed Apr. 9, 1993 PCT Pub. No. WO93/21186 PCT Pub. Date Oct. 28, 1993A compound of the formula: in which R1 is carboxy or protected carboxy, R2 is 1-hydroxyethyl, R3 is methyl, R4 is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lower)alkyl, optionally substituted imidazol-1-yl(C2-C3)alkyl, optionally substituted imidazol-5-yl-(lower)alkyl, optionally substituted imidazol-2-yl-(lower)alkyl, optionally substituted pyrazol-4-(or 5-)yl(lower)alkyl, optionally substituted pyrazol-1-ylethyl, optionally substituted triazolyl(lower)alkyl, optionally substituted pyrimidinyl(lower)alkyl, optionally substituted dihydropyrimidinyl(lower)alkyl, or optionally substituted (2,3-dihydroimidazo-[1,2-b]pyrazol-1-yl)ethyl, and R5 is hydrogen or imino-protective group, and pharmaceutically acceptable salts thereof, which have antimicrobial activity.
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Inventors:
Masayoshi Murata
Hideo Tsutsumi
Keiji Matsuda
Koji Hattori
Hisashi Nakashima
Hideo Tsutsumi
Keiji Matsuda
Koji Hattori
Hisashi Nakashima
Application Number:
JP51818093A
Publication Date:
January 14, 2003
Filing Date:
April 09, 1993
Export Citation:
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
International Classes:
C07D477/00; A61K31/397; A61K31/40; A61P31/00; A61P31/04; C07D477/20; C07D487/04; C07D519/00; C07D521/00; (IPC1-7): C07D477/00; A61K31/40; A61P31/00; C07D519/00
Domestic Patent References:
| JP3188078A | ||||
| JP215080A | ||||
| JP21491A |
Attorney, Agent or Firm:
Eiji Tabuse