Title:
【発明の名称】良性前立腺過形成に特異的な型の前立腺特異抗原(PSA)とその利用法
Document Type and Number:
Japanese Patent JP2002542820
Kind Code:
A
Abstract:
A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid sequence of a mature form of PSA. Preferably, the novel form of PSA additionally comprises one or more clips at a location selected from a group consisting of Ile 1, Lys 145, and Lys 146. More preferably, the form of PSA contains at least two clips at Lys 145 and Lys 182 of the amino acid sequence of a mature form of PSA. The novel forms of PSA exist at an elevated level in patients suspected of having benign prostatic hyperplasia (BPH) and therefore may be used as a serum mark or an immunohistological marker to help distinguish BPH from prostate cancer. Antibodies recognizing the novel forms of PSA and immunoassays that detect and determine the novel forms of PSA of the present invention in a sample are also provided. Further provided are a kit and a method for detecting the novel forms of PSA for aiding in the differentiation of prostate cancer from BPH.
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Inventors:
Micoraiji, Stephen
One, tan
Rittenhouse, Harry
Wolfert, Robert
Slow win, kevin
One, tan
Rittenhouse, Harry
Wolfert, Robert
Slow win, kevin
Application Number:
JP2000615743A
Publication Date:
December 17, 2002
Filing Date:
April 07, 2000
Export Citation:
Assignee:
Hybridec Incorporated
BAYLOR COLLEGE OF MEDICINE
BAYLOR COLLEGE OF MEDICINE
International Classes:
C07K16/40; C12N5/10; C12N9/64; C12N15/02; C12P21/08; G01N33/577; G01N33/573; A61K35/12; A61K48/00; C12R1/91; (IPC1-7): C12N9/64; C07K16/40; C12N5/10; C12N15/02; C12P21/08; G01N33/573; G01N33/577
Foreign References:
| WO1998043084A1 | 1998-10-01 |
Attorney, Agent or Firm:
Matsunaga Nobuyuki