Title:
生体高分子とリガンドとの相互作用を検出する装置及びその方法
Document Type and Number:
Japanese Patent JP4809983
Kind Code:
B2
Abstract:
A apparatus is provided for detecting interactions between biomolecules and ligands, the apparatus comprises: a reaction block constituting a reaction system comprising a reaction region including immobilized biomolecules, a supply flow channel connected to the reaction region for supplying a sample solution, and a recovery flow channel connected to the reaction region for recovering the sample solution which passes through at least a part of the reaction region; and a measuring block for measuring streaming potential of the immobilized biomolecules while the sample solution is supplied to the reaction region from the supply flow channel and the sample solution passing through at least a part of the reaction region is collected by the recovery flow channel. Thereby it is possible to detect interactions between a number of biomolecules and ligands at one time.
Inventors:
Akihiko Tanioka
Yutaka Yamagata
Kozo Inoue
Yutaka Yamagata
Kozo Inoue
Application Number:
JP2001037141A
Publication Date:
November 09, 2011
Filing Date:
February 14, 2001
Export Citation:
Assignee:
Akihiko Tanioka
RIKEN
Fuence Co., Ltd.
RIKEN
Fuence Co., Ltd.
International Classes:
G01N27/26; G01N33/566; B01L3/00; G01N27/327; G01N27/414; G01N33/53; G01N33/543
Domestic Patent References:
| JP6265551A | ||||
| JP10104188A | ||||
| JP10332621A | ||||
| JP7239313A | ||||
| JP2257052A | ||||
| JP4050758A | ||||
| JP2000019144A |
Other References:
Victor N.Morozov et al.,Electrospray Deposition as a Method To Fabricate Functionally Active Protein Films,Anal.Chem. ,1999年,Vol.71,p.1415-1420
Victor N.Morozov et al.,Electrospray Deposition as a Method for Mass Fabrication of Mono-and Multicomponent Microarrays of Biological and Biologically Active Substances,Anal.Chem.,1999年,Vol.71,p.3110-3117
Sabine Koch et al.,Protein detection with a novel ISFET-based zata potential analyzer,Biosensors & Bioelectronics,,1999年,Vol.14,,p.413-421,
Victor N.Morozov et al.,Electrospray Deposition as a Method for Mass Fabrication of Mono-and Multicomponent Microarrays of Biological and Biologically Active Substances,Anal.Chem.,1999年,Vol.71,p.3110-3117
Sabine Koch et al.,Protein detection with a novel ISFET-based zata potential analyzer,Biosensors & Bioelectronics,,1999年,Vol.14,,p.413-421,
Attorney, Agent or Firm:
Kosaku Sugimura