ジアゾ二環式SMAC模倣物およびその使用 - The Regents of the University of Michigan

Title:

ジアゾ二環式SMAC模倣物およびその使用

Document Type and Number:

Japanese Patent JP5416089

Kind Code:

B2

Abstract:

The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

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Inventors:

One Xiamen
Pan Yue Fung
Sun High Inn
Kai Chien
Nikolovska-Coleska Zaneta
Lucien Fung
Kyusu

Application Number:

JP2010503269A

Publication Date:

February 12, 2014

Filing Date:

April 14, 2008

Export Citation:

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Assignee:

The Regents of the University of Michigan

International Classes:

C07D487/04; A61K31/407; A61K31/4178; A61K31/4439; A61K45/00; A61P35/00; A61P35/02; A61P43/00

Domestic Patent References:

JP2005504043A

Foreign References:

WO2007130626A1
WO2006010118A1
WO2005069894A1

Other References:

Tetrahedron Lett.,2006年,47,4769-4770
LENMAN,JOURNAL CHEMICAL SOCIETY PERKINS TRANS,1997年 7月28日,P2297-2311
Amino Acids,2005年,29,131-138

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto

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