Title:
DIBENZOXAZEPIN DERIVATIVE
Document Type and Number:
Japanese Patent JPS572278
Kind Code:
A
Abstract:
NEW MATERIAL:A dibenzoxazepin derivative of formula I (R1 is H, 1W2 halogens, lower alkyl, or lower alkoxy; R2 is H or lower alkyl).
EXAMPLE: 8-Ethoxycarbonyldibenzo[b,f][1,4]oxazepin-11(10H)one.
USE: It has antilipemic activity, antiulcer activity, and PGI2-production promoting activity, and is useful as a medicine.
PROCESS: The compound of formula I is prepared by the thermal cyclization of diphenyl ether of formula II (R3 and R4 are lower alkyl) without using a solvent or in a solvent such as toluene, xylene, etc. pref. at 100W200°C, followed by hydrolysis of the prodct if necessary.
Inventors:
KOIZUMI MASUO
SASAHARA KAZUO
MURAKAMI YASUSHI
NEICHI TOMOHIRO
YAMAZAKI TAMOTSU
MATSUSHITA KOUJI
HATA SHIYUNICHI
SASAHARA KAZUO
MURAKAMI YASUSHI
NEICHI TOMOHIRO
YAMAZAKI TAMOTSU
MATSUSHITA KOUJI
HATA SHIYUNICHI
Application Number:
JP7417680A
Publication Date:
January 07, 1982
Filing Date:
June 04, 1980
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C07D267/20; A61K31/55; A61P1/04; A61P3/06; A61P43/00; (IPC1-7): A61K31/55; C07D267/20
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