Title:
慢性関節リウマチの疾患感受性遺伝子、及びその利用
Document Type and Number:
Japanese Patent JP4242590
Kind Code:
B2
Abstract:
A rheumatoid arthritis disease sensitivity gene (I) encoding Angiopoietin-1 protein having a fully defined sequence of 498 amino acids (S1), given in the specification which has a glycine insertion variation at position 269, is new. Independent claims are included for the following: (1) protein (II) consisting of (S1) and a glycine insertion variation at the 269 position of the sequence; (2) determining the onset of rheumatoid arthritis; (3) determining the onset of rheumatoid arthritis by detecting the presence or absence of (I) or (II), or by using determination kit; (4) treating rheumatoid arthritis; and (5) therapeutic drug used for treatment of rheumatoid arthritis in a patient who has (II). ACTIVITY : Antirheumatic; Antiarthritic. No biological data is given. MECHANISM OF ACTION : Angiopoietin-1 protein agonist; Gene therapy.
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Inventors:
Shunichi Shiozawa
Koichiro Komai
Mikiko Nakatsu
Koichiro Komai
Mikiko Nakatsu
Application Number:
JP2002005326A
Publication Date:
March 25, 2009
Filing Date:
January 11, 2002
Export Citation:
Assignee:
Shunichi Shiozawa
New Industry Creation Research Institute
New Industry Creation Research Institute
International Classes:
C12N15/09; A61K38/00; A61K38/17; A61K45/00; A61K48/00; A61P19/02; A61P29/00; C07K14/47; C07K14/515; C12N15/12; C12Q1/68; G01N33/50; G01N33/564
Foreign References:
| WO2000064946A1 | ||||
| WO1996031598A1 | ||||
| WO2000002587A1 |
Other References:
Ann. Rheum. Dis., (2000), Vol. 59, p. 607-614
Arthritis & Rheumatism, (2001), Vol. 44, No. 4, p. 794-801
Cell, (1996), Vol. 87, p. 1161-1169
Arthritis & Rheumatism, (2001), Vol. 44, No. 4, p. 794-801
Cell, (1996), Vol. 87, p. 1161-1169
Attorney, Agent or Firm:
Kenzo Hara