Title:
代謝性骨疾患治療用薬剤組成物及びその製造方法
Document Type and Number:
Japanese Patent JP4875818
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition for the treatment of metabolic bone disease and the method of preparation thereof, and more particularly, to an improved pharmaceutical composition for the therapeutic treatment of metabolic disease and the method of preparation thereof, wherein said composition is prepared as a composite pharmaceutical agent which comprises calcitriol; which reduces the rate of spine fractures and increases bone density; alendronate, a bone resorption inhibitor, as two main active ingredients in an optimal mixing ratio to exert the greatest synergistic therapeutic effect; and adequate amount of other additives such as a resorption fortifier of alendronate. Thereof, the pharmaceutical composition according to the present invention can inhibit hypercalcemia caused when administered by calcitriol alone, compensate the inhibitory activity of bone remodeling caused by alendronate due to the presence of calcitriol, and improve drug compliance associated with the usual difficulty in administration as well as a side effect in esophagus, thus effectively preventing the occurence of osteoporosis.
Inventors:
Kang Sung An
Lee Kyung Hee
Kak Chong Sil
Kim Chang Jung
Lee Young Woo
Lee Kyung Hee
Kak Chong Sil
Kim Chang Jung
Lee Young Woo
Application Number:
JP2001531394A
Publication Date:
February 15, 2012
Filing Date:
October 20, 2000
Export Citation:
Assignee:
YUYU INC.
International Classes:
A61K31/663; A61K9/16; A61K9/20; A61K9/28; A61K9/48; A61K9/50; A61K31/59; A61K31/593; A61K31/66; A61K47/10; A61K47/26; A61P19/08; A61P19/10
Domestic Patent References:
| JPH1160489A | 1999-03-02 | |||
| JPH07330613A | 1995-12-19 |
Attorney, Agent or Firm:
Kosaku Sugimura
Kenji Sugimura
Kazuyuki Tomita
Kenji Sugimura
Kazuyuki Tomita