Title:
デュアルMAGL及びFAAHインヒビター
Document Type and Number:
Japanese Patent JP7440572
Kind Code:
B2
Abstract:
Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The compounds and pharmaceutical compositions are further useful for the treatment of pain and neurological disorders.
Inventors:
Cheryl A. Grice
Justin S. Chisal
Catherine Kay Duncan
Youfeng
John Jay M. Wiener
Olivia Dee Webber
Justin S. Chisal
Catherine Kay Duncan
Youfeng
John Jay M. Wiener
Olivia Dee Webber
Application Number:
JP2022105683A
Publication Date:
February 28, 2024
Filing Date:
June 30, 2022
Export Citation:
Assignee:
Lundbeck La Jolla Research Center, Inc.
International Classes:
C07D401/12; A61K31/444; A61K31/455; A61K31/501; A61K31/506; A61P1/04; A61P25/00; A61P25/02; A61P25/04; A61P25/22; A61P29/00; A61P35/00; C07D471/10
Domestic Patent References:
JP2012526784A | ||||
JP2006088075A1 | ||||
JP7178375B2 | ||||
JP2022068197A |
Foreign References:
WO2010141817A1 | ||||
WO2011136308A1 | ||||
WO2017021805A1 |
Other References:
KEITH,J.M. et al.,Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase,Bioorganic & Medicinal Chemistry Letters,2014年,Vol.24, No.3,p.737-741
野崎正勝 等,創薬化学,第1版,株式会社化学同人,1995年,p.98-99
MEYERS,M.J. et al.,Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds,Bioorganic & Medicinal Chemistry Letters,2011年,Vol.21, No.21,p.6538-6544
野崎正勝 等,創薬化学,第1版,株式会社化学同人,1995年,p.98-99
MEYERS,M.J. et al.,Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds,Bioorganic & Medicinal Chemistry Letters,2011年,Vol.21, No.21,p.6538-6544
Attorney, Agent or Firm:
Toru Ishikawa
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