Title:
DUAL ACTION INHIBITOR
Document Type and Number:
Japanese Patent JP3487611
Kind Code:
B2
Abstract:
PURPOSE: To obtain new compds. useful as dual inhibitors having inhibitory activity against angiotensin converting enzyme and neutral endopeptidase in the treatment of hypertension, congestive heart failure, hepatocirrhosis, etc.
CONSTITUTION: The new compds. are compds. of formula I {R1 is H, a group of formula II [R3 is alkyl, aryl-(CH2)m-[(m) is 0-6] or the like] or the like; R2 and R19 are each H, alkyl or the like; (n) is 0 or 1 but (n) is 0 when both R2 and R19 are other than H; and X1 is a group of formula III or IV [Y2 is CH3, O or the like; (w) is 1 or 2; and R12 is H, substd. alkyl or the like] or the like}, e.g. [S-(R*,R*)]-2,3,4,5-tetrahydro-3-[(2-mercapto-1-oxohexyl)amino]-2- oxo-1H-benzazepine-1-acetic acid. A compd. of the formula I (R1 is a group of the formula II and R19 is H) is obtd. by reacting an acylmercaptocarboxylic acid of formula V with an intermediate of the formula H-X2 (R2 in X1 is an ester protecting group) and releasing the protecting group R12 from the resultant product.
Inventors:
Donald S. Karaneuski
Joel Sea Balish
Edward W Petrillo, Jr.
Jeffrey A. Roble
Dennis E. Riono
Joel Sea Balish
Edward W Petrillo, Jr.
Jeffrey A. Roble
Dennis E. Riono
Application Number:
JP11587493A
Publication Date:
January 19, 2004
Filing Date:
May 18, 1993
Export Citation:
Assignee:
E.R. SQUIBB & SONS,INCORPORATED
International Classes:
A61K31/395; A61K31/4353; A61K31/54; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61K38/00; A61K38/55; A61P1/16; A61P9/04; A61P9/12; A61P13/12; A61P43/00; C07D211/76; C07D223/10; C07D223/12; C07D223/16; C07D225/02; C07D225/06; C07D233/16; C07D243/02; C07D243/08; C07D267/08; C07D267/14; C07D279/00; C07D223/24; C07D279/06; C07D281/00; C07D281/02; C07D281/04; C07D281/06; C07D281/10; C07D281/18; C07D283/00; C07D283/02; C07D285/36; C07D313/04; C07D313/08; C07D403/12; C07D455/02; C07D471/04; C07D487/02; C07D487/04; C07D498/04; C07D513/02; C07D513/04; C07K1/113; C07K5/06; C07K5/078; C07K14/81; (IPC1-7): C07D223/16; A61K31/395; A61K31/54; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61K38/00; A61P1/16; A61P9/04; A61P9/12; A61P13/12; A61P43/00; C07D223/10; C07D225/02; C07D225/06; C07D243/02; C07D267/14; C07D279/06; C07D281/06; C07D281/10; C07D487/04; C07D513/04; C07K5/06
Domestic Patent References:
| JP7506832A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)