To find out a substance having an endothelin-1 mRNA expression elevation inhibitory activity, an SCFmRNA expression elevation inhibitory activity, a bFGFmRNA expression elevation inhibitory activity or a POMCmRNA expression elevation inhibitory activity, and to provide an endothelin-1 mRNA expression elevation inhibitor, an SCFmRNA expression elevation inhibitor, a bFGFmRNA expression elevation inhibitor or a POMCmRNA expression elevation inhibitor by using the above substance as an active ingredient.

This extract of yucca is incorporated to the endothelin-1 mRNA expression elevation inhibitor, SCFmRNA expression elevation inhibitor, bFGFmRNA expression elevation inhibitor or POMCmRNA expression elevation inhibitor as the active ingredient.